About the Lab
We study Humoral Immunity, Influenza Viruses, and Everything in BetweenOur lab is interested in understanding the complexities of humoral immunity against rapidly evolving viruses. Our lab has three major interests -
Manipulating host factors to improve humoral immunity: Robust and broad humoral immunity against influenza viruses is rarely induced for unclear reasons. Our group is developing novel models to investigate the host factors that limit protective humoral immunity and how distinct vaccines and adjuvants can overcome these limitations. Zoonotic Influenza Viruses and Broadly Protective Humoral Immunity: Zoonotic influenza viruses pose a threat to human health. Our group is developing methods to rapidly screen preexisting human antibody responses against pandemic-threat influenza viruses as well as using humoral immunity to screen for viral spillover. We are also investigating humoral immunity in important animal reservoirs, including pigs and ducks. Co-evolution of humoral immunity and influenza viruses: Humans are exposed to influenza viruses throughout their lives. We are interested in understanding how the first and repeated exposures shape the human B cell repertoire against influenza viruses. Conversely, we are interested in understanding how constantly evolving antibody responses shape viral evolution, pathogenesis, and selection. |
Courtesy of Lei Li, PhD
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News
7/29/25
Congratulations to Jordan for completing his Master's degree! Jordan will stay in the lab as a research services professional to continue his research on how antibodies drive antigenic drift of H1N1 viruses.
1/23/25
Marina, Devika, and Jenna published a Plos Pathogens Pearl Article on H5N1 receptor binding.
12/30/24
"A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth." is now published at Nature Communications! Congratulations to the team for all their hard work!
9/17/24
Jenna is announced as the winner of the 2024 James S. Huston Antibody Science Talent Award by the Antibody Society!
9/2/24
Elizabeth Gilliland, MS, joins the lab as a Research Services Professional. Welcome, Elizabeth!
7/24/24
Marina won the 2nd Place Prize for Most Innovative Poster at the Annual Center of Excellence in Influenza Research and Response Meeting in New York, NY! Congratulations on a great job!
7/18/24
Lauren Immink wrote a methods chapter entitled "Isolation of rare antigen-specific memory B cells via Antigen Tetramers" published in the Methods in Molecular Biology "Memory B-Cells" book. Great work, Lauren!
7/15/24
Alex Dickson joins the lab as a postdoctoral fellow. Welcome, Alex!
6/25/24
Jenna is announced as a winner of the Ann Palmenberg Junior Investigator Award at the 2024 American Society for Virology Meeting!
6/23/24
Members of the Guthmiller lab (Marina and Wei), along with a collaboration with Andrew Ward's lab have a pre-print on BioRxiv titled "A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth."
5/22/24
Jordan Lemus-Reyes joins the lab for his Master's thesis. Welcome, Jordan!
5/14/24
Lena and Jenna publish a preview in Immunity.
2/15/24
Wei and Jenna publish an editorial in the Journal of Infectious Disease.
1/1/24
Marina received a predoctoral fellowship from the American Heart Association. Congratulations, Marina!!
9/11/23
Mackenzie Amrine and Alyssa Monterroso join the lab at Research Services Professionals. Welcome, Mackenzie and Aly!
8/31/23
Marina and Wei both win AAI Young Investigator Awards for their poster presentations at the 22nd Annual Colorado Immunology and Microbiology Conference!
8/22/23
The lab receives its first 5-year grant (DP2) from the National Institute of Allergy and Infectious Diseases! In collaboration with Dr. Tim Whitehead at CU Boulder, we will be designing a vaccine to shift humoral immunity towards broadly protective epitopes of HA.
7/4/23
Jenna is announced as the recipient of the 2023 ESWI Young Scientist Vaccine Innovation Award!
7/1/23
Sarah Leach joins the lab for her PhD research. Welcome, Sarah!
1/26/23
The lab is now supported by the Emerging Pathogens Initiative sponsored by the Howard Hughes Medical Institute! Together with collaborators at the University of Illinois Urbana-Champaign, we will be investigating antibody responses against avian influenza viruses at the human and avian interface, with a major focus on ducks.
1/24/23
Jenna is announced as one of the winners of the 2022 Michelson Prize! This funded research project will investigate the B cell specificities within the respiratory tract as well as test how next-generation influenza vaccines promote broadly protective antibody responses.
1/9/23
Lena Hansen joins the lab as a Postdoctoral Fellow. Welcome, Lena!
11/1/22
Lauren Immink joins the lab as a Laboratory Sciences Professional. Welcome, Lauren!
10/10/22
Wei Ji joins the lab as a Postdoctoral Fellow. Welcome, Wei!
10/10/22
Edgar Ayala joins the lab as a Laboratory Sciences Professional. Welcome, Edgar!
9/12/22
Marina and Jenna publish a commentary in mBio!
8/15/22
Marina Good joins the lab for her PhD research. Welcome, Marina!
7/1/22
Devika Suja joins the lab as a Professional Research Assistant II. Welcome, Devika!
7/1/22
The Guthmiller Lab opens at the University of Colorado Anschutz Medical Campus in the Department of Immunology and Microbiology!
Congratulations to Jordan for completing his Master's degree! Jordan will stay in the lab as a research services professional to continue his research on how antibodies drive antigenic drift of H1N1 viruses.
1/23/25
Marina, Devika, and Jenna published a Plos Pathogens Pearl Article on H5N1 receptor binding.
12/30/24
"A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth." is now published at Nature Communications! Congratulations to the team for all their hard work!
9/17/24
Jenna is announced as the winner of the 2024 James S. Huston Antibody Science Talent Award by the Antibody Society!
9/2/24
Elizabeth Gilliland, MS, joins the lab as a Research Services Professional. Welcome, Elizabeth!
7/24/24
Marina won the 2nd Place Prize for Most Innovative Poster at the Annual Center of Excellence in Influenza Research and Response Meeting in New York, NY! Congratulations on a great job!
7/18/24
Lauren Immink wrote a methods chapter entitled "Isolation of rare antigen-specific memory B cells via Antigen Tetramers" published in the Methods in Molecular Biology "Memory B-Cells" book. Great work, Lauren!
7/15/24
Alex Dickson joins the lab as a postdoctoral fellow. Welcome, Alex!
6/25/24
Jenna is announced as a winner of the Ann Palmenberg Junior Investigator Award at the 2024 American Society for Virology Meeting!
6/23/24
Members of the Guthmiller lab (Marina and Wei), along with a collaboration with Andrew Ward's lab have a pre-print on BioRxiv titled "A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth."
5/22/24
Jordan Lemus-Reyes joins the lab for his Master's thesis. Welcome, Jordan!
5/14/24
Lena and Jenna publish a preview in Immunity.
2/15/24
Wei and Jenna publish an editorial in the Journal of Infectious Disease.
1/1/24
Marina received a predoctoral fellowship from the American Heart Association. Congratulations, Marina!!
9/11/23
Mackenzie Amrine and Alyssa Monterroso join the lab at Research Services Professionals. Welcome, Mackenzie and Aly!
8/31/23
Marina and Wei both win AAI Young Investigator Awards for their poster presentations at the 22nd Annual Colorado Immunology and Microbiology Conference!
8/22/23
The lab receives its first 5-year grant (DP2) from the National Institute of Allergy and Infectious Diseases! In collaboration with Dr. Tim Whitehead at CU Boulder, we will be designing a vaccine to shift humoral immunity towards broadly protective epitopes of HA.
7/4/23
Jenna is announced as the recipient of the 2023 ESWI Young Scientist Vaccine Innovation Award!
7/1/23
Sarah Leach joins the lab for her PhD research. Welcome, Sarah!
1/26/23
The lab is now supported by the Emerging Pathogens Initiative sponsored by the Howard Hughes Medical Institute! Together with collaborators at the University of Illinois Urbana-Champaign, we will be investigating antibody responses against avian influenza viruses at the human and avian interface, with a major focus on ducks.
1/24/23
Jenna is announced as one of the winners of the 2022 Michelson Prize! This funded research project will investigate the B cell specificities within the respiratory tract as well as test how next-generation influenza vaccines promote broadly protective antibody responses.
1/9/23
Lena Hansen joins the lab as a Postdoctoral Fellow. Welcome, Lena!
11/1/22
Lauren Immink joins the lab as a Laboratory Sciences Professional. Welcome, Lauren!
10/10/22
Wei Ji joins the lab as a Postdoctoral Fellow. Welcome, Wei!
10/10/22
Edgar Ayala joins the lab as a Laboratory Sciences Professional. Welcome, Edgar!
9/12/22
Marina and Jenna publish a commentary in mBio!
8/15/22
Marina Good joins the lab for her PhD research. Welcome, Marina!
7/1/22
Devika Suja joins the lab as a Professional Research Assistant II. Welcome, Devika!
7/1/22
The Guthmiller Lab opens at the University of Colorado Anschutz Medical Campus in the Department of Immunology and Microbiology!
